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4-Methylmethcathinone (also known as 4-MMC, M-CAT, drone, meow meow, and mephedrone) is a novel entactogen-stimulant substance of the cathinone class. Mephedrone belongs to a group known as the substituted cathinone, which are derivatives of the active ingredient in the khat plant (Catha edulluis).
Mephedrone was first synthesized in 1929, but did not become widely known until it was rediscovered in 2003. By 2007, it was reported to be available for sale on the internet, by 2008 law enforcement agencies had become aware of the compound, and by 2010 it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom.
It comes in the form of tablets or a powder, which users can swallow, snort, inject or insert rectally, producing effects which are somewhat similar to those of MDMA, amphetamine, and cocaine. It is reported to produce a mixture of classic stimulant and entactogenic effects effects reminiscent of cocaine and MDMA.
Research Chemicals of mephedrone 4 mmc
Mephedrone, or 4-methylmethcathinone, is a synthetic molecule of the cathinone family. Cathinones are structurally similar to amphetamines, they contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at RÎ±. Amphetamines and cathinones are alpha-methylated phenethylamines, cathinones contain an additional carbonyl group at R1. Mephedrone contains an additional methyl substitutions at RN, similarly to MDMA and methamphetamine, and R4 of its phenyl ring.
Pharmacology of Mephedrone 4MMC
Given its chemical structure, mephedrone is likely to act as a releasing agent and a reuptake inhibitor for monoamine neurotransmitters such as dopamine, serotonin and noradrenaline.
Several articles published near the end of 2011 examined the effects of mephedrone in the brains of rats, as well as examining the reinforcing potential of mephedrone. Dopamine and serotonin were collected using microdialysis, and increases in dopamine and serotonin were measured. Mephedrone administration caused about a 500% increase in dopamine, and about a 950% increase in serotonin. They reached their peak concentrations at 40 minutes and 20 minutes and returned to baseline by 120 minutes after injection.
Analysis of the ratio for dopamine and serotonin indicated mephedrone was preferentially a serotonin releaser, with a ratio of 1.22:1 (serotonin vs. dopamine). Additionally, half-lives for the decrease in dopamine and serotonin were calculated and found to have decay rates of 24.5 minutes and 25.5 minutes.
These findings show mephedrone induces a massive increase in both dopamine and serotonin, combined with rapid clearance. This increase in neurotransmitters provides an explanation for the euphoric and stimulating subjective effects induced by this experience. The rapid rise and subsequent fall of dopamine levels could also explain some of the addictive properties of mephedrone display in some users.
Mephedrone (4-MMC / 4-methylmethcathinone)
is a well-known cathinone that acts as a stimulant and empathogenic for mephedrone / 4-MMC, and is among the research chemicals that have been illegalized in most countries worldwide for several years.
4-MMC reached a very high popularity status, after the prohibition it is still on the black market to find, but ostensibly the quality should not be able to keep up with the mephedrone before the ban (the so-called Pre-Ban Mephedrone). According to many consumers who took mephedrone before the illegalization of the current 4-MMC cause a much less strong & euphoric effect, which should not be compensated by increasing the dose.
This may be true, but it may also be due to transfigured memories, receptors destroyed by excessive consumption, or tolerance development.
It is certain that there are strong differences in the quality of the available mephedrone, since the synthesis as well as amphetamine, MDMA & co. can only be done illegally and accordingly unregulated.
The effect of mephedrone may be considered to be comparable to cocaine, but it is more empathogenic than egopushing.
The euphoric effect is usually much more noticeable than the stimulating one, the more it is refilled, the weaker is the euphoria.
There are many different substances that are being marketed as mephedrone substitutes, many consumers are looking for a similarly intensive stimulant and are ready to take many, sometimes very unknown, cathinones. The most popular substitute is 3-MMC, which has also been illegalized in most countries (including Germany).
We have already introduced several other cathinone and mephedrone alternatives such as 3-MMC, 3-CMC, 4-CMC, 4-MEC and Mexedron.
4-MMC is usually offered as HCl in pure form (as powder or crystals). Solubility data refer to Mephedrone HCl.
Other names: mephedrone, mephedrone, 4-MMC, 4-methylmethcathinone, 4-methylmethcathinone, 4-methyl-ephedron, 4-methyl-ephedrone, 4-methylephedrone, 4-methylephedrone (engl.) , 4-MeMC, M-CAT, Meow Meow, Drone, Mephe,
IUPAC: (RS) -2-methylamino-1- (4-methylphenyl) propan-1-one, (RS) -2-methylamino-1- (4-methylphenyl) propan-1-one (English)
Molecular formula: C11H15NO
Molecular mass: 177.242 g / mol
There is not enough information about this substance!
Hardly any reports from consumers and certainly very few scientific papers.
Accordingly, the consumption is an unpredictable risk, possible toxic effects may be undetected.
We strongly advise against taking it!
The following information is a collection of information taken from reports about this designer drug. We can not guarantee the accuracy and recommend to anyone to consult further sources.
Â Effect of mephedrone 4mmc
The effects and side effects listed here are all very subjective and are perceived differently by each person.
They do not always have to occur and there may be other, unmentioned effects. (Then we would be pleased about a comment on this!)
These lists should not serve as a guarantee, but as a guide.
Stimulation (stimulating, awakening)
Concentration and performance increase
Aphrodisiac – increase sexual desire and delay orgasm, is very strong!
Increased Rededrang – A so-called “Laberflash”
Euphoric – This is probably the most important active component of this substance. Good mephedrone should be much more euphoric than 3-MMC, comparable to the euphoria with cocaine or MDMA, it is much more pronounced than in pure stimulants such as amphetamine, 2-MMC or 2-FA.
Empathic – 4-MMC can increase empathy for other people.
Mephedrone 4 MMC is an Upper that is not overly stimulating, but very euphoric and empathogenic (sometimes increasing self-esteem).
It is therefore by no means a “working drug” or a performance-enhancing stimulant, but rather a party drug / fun drug.
Since euphoria is a very important component of the effect, the addictive potential is significantly higher than with amphetamine, 2-MMC, 2-FA etc., more comparable to cocaine, methamphetamine or MDPV.
In general, the effect is Cathinone-typical, people who have never consumed cathinone may imagine it to be similar to cocaine, with MDMA-like effects also present, 4-MMC is considered more empathic than cocaine.
The aphrodisiac effect is very strong, the orgasm is intensified. Because of this, sexual intercourse after having experienced sex on mephedrone (or other upsets) is less fun than before for some consumers, which may also be a reason for addiction.
It makes a big difference whether you consume 4-methylmethcathinone orally or nasally.
In oral use, the effect is much more subtle and is sometimes described as MDMA-like, nasally the effect is much harder, more severe & cocaine-like.
Compared to 3-MMC (3-methylmethcathinone), mephedrone is usually much more euphoric and intense!
Consumer forms / application routes
Common is the oral and nasal consumption of 4mmc
When used orally, the effect is a little less intense and lasts much longer.
In nasal consumption, it starts faster and stops shorter, which leads to significantly more craving (ie, greed for the substance / Nachlegedrang).
In addition, the nasal mucosa are severely damaged by the substance, it can cause nosebleeds, etc. If the mephedrone is obtained in crystalline form, it should be comminuted as well as possible because coarse crystals cause fine cuts.
More Safer Use Infos (also for Safer Sniffing) are here!
Also intravenous, inhalative, rectal and sublingual consumption is possible, but little is known about these forms of consumption.
Inhalative use is very dangerous and harmful, the craving is enormous and you have to choose significantly lower dosages, some consumers also report violent palpitations and other side effects.
The same applies to intravenous consumption, here comes the serious damage to the veins added.
Although rectal use is slightly less harmful than inhaled and intravenous use, it can still damage the intestinal mucosa and produce a tremendously strong effect.
Mephedrone dose / dosage
These dosage indications are only approximate guidelines derived from consumer reports.
It must be started with an allergy test and a very low dose!
More Safer Use rules can be found here.
First effects from: 15-50mg
Light effect: 50-100mg
Strong effect: 150-300mg
Very strong effect: 300mg +
First effects from: 5-15mg
Light effect: 15-25mg
Strong effect: 75-125mg
Very strong effect: 125mg +
4MMC – time of action
Effect on after: 15-45 minutes
Main effect: 2-4 hours
Coming down: 30-90 minutes
Afterglow: 2-6 hours
Effect on after: 10-30 minutes
Main effect: 1-3 hours
Coming down: 30-90 minutes
Afterglow: 2-6 hours
Most likely, mephedrone acts as a dopamine, norepinephrine & serotonin reuptake inhibitor and shedding.
How exactly it works in the human brain has not been clarified, but there are some animal studies in rats, which showed that the dopamine and serotonin levels in the brain was increased.
The serotonin concentration was increased more than the dopamine concentration at a rate of 1.22: 1 (serotonin: dopamine).
Mixed consumption mephedron and dangerous combinations
Mixed consumption mephedron 4-mmc is basically a drastic increase in risk.
Every single combination has to be informed in advance and experience reports must be searched for as there can always be dangerous interactions.
Other stimulants: The mixed use of different stimulants is potentially very dangerous as the blood pressure and heart rate are greatly increased and side effects such as dehydration are also increased.
In a scientific study, it was found that mephedrone in mixed use with methamphetamine, amphetamine and MDMA in rats resulted in a greatly increased NerotoxizitÃ¤t!
Here is the study.
The effect can unpredictably potentiate and there can be dangerous interactions (such as severe neurotoxicity or a serotonin syndrome), so you have to know exactly about every single combination that you want to take!
25X-NBOMe, 25x-NBF & co .: The amphetamine analogues of psychedelic phenethylamines, such as 25x-NBOMe, 25x-NBF, etc., are in themselves stimulating and stimulating and have a strong effect on heart rate and blood pressure.
The mixed consumption of stimulants with this psychedelic is life threatening!
Psychedelics: Other psychedelics can also cause complications with blood pressure and circulation when mixed with stimulants.
Also, the psychic side is not to be underestimated, since the upper paranoia and increase the risk of a dip trip.
DXM & other dissociative: The mixed use of DXM (and other dissociatives) with stimulants can be very dangerous. Blood pressure and heart rate are increased and also here it can come to mental problems (panic attacks, Badtrip).
Alcohol: greatly increased dehydration! The effect of the alcohol is suppressed by the Upper, so it can no longer be estimated whether drinking too much.
This can lead to alcohol poisoning, which can be life-threatening.
Tramadol, Kratom & other opioids: The seizure threshold is greatly reduced in mixed use, which can easily lead to seizures.
MDMA & similar empathogens as MDAI, methylone, 5-MAPB etc .: The neurotoxic effects of MDMA are intensified by mixed use with upsets, the hangover the next day is significantly worse.
As mentioned above, there is a study examining the effect of mephedrone in mixed use with MDMA in rats, where there is an increased neurotoxicity.
Here is the study.
MAO inhibitor: deadly combination! Attention!
Downer: The combination of upsets and downers (like benzodiazepines, opioids, alcohol & GBL) can lead to a dangerous circulatory load.
Heart rate and blood pressure can be increased.
In addition, the sedative component of the downer is suppressed, which is why it can easily come to an overdose, because the consumer can no longer estimate how strong the effect of the downer is already and he therefore possibly nachlegen.
4-MMC Mephedrone Store
We are one of the best partners when it come to research chemical like mephedrone and our purity is 99%.Mephedrone, also known as 4-methyl methcathinone (4-MMC) or 4-methyl ephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include drone,It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa. It comes in the form of tablets or a powder, which users can swallow, snort or inject, producing similar effects to MDMA, amphetamines and cocaine.In addition to its stimulant effects, mephedrone produces side effects, of which teeth grinding is the most common. The metabolism of mephedrone has been studied in rats and humans and the metabolites can be detected in urine after usage.Wost customers that have ordered from us know more about the product.
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